Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Identifieur interne : 001F70 ( Main/Exploration ); précédent : 001F69; suivant : 001F71Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Auteurs : Catherine J. Reynolds [Royaume-Uni] ; Leo Swadling [Royaume-Uni] ; Joseph M. Gibbons [Royaume-Uni] ; Corinna Pade [Royaume-Uni] ; Melanie P. Jensen [Royaume-Uni] ; Mariana O. Diniz [Royaume-Uni] ; Nathalie M. Schmidt [Royaume-Uni] ; David K. Butler [Royaume-Uni] ; Oliver E. Amin [Royaume-Uni] ; Sasha N L. Bailey [Royaume-Uni] ; Sam M. Murray [Royaume-Uni] ; Franziska P. Pieper [Royaume-Uni] ; Stephen Taylor [Royaume-Uni] ; Jessica Jones [Royaume-Uni] ; Meleri Jones [Royaume-Uni] ; Wing-Yiu Jason Lee [Royaume-Uni] ; Joshua Rosenheim [Royaume-Uni] ; Aneesh Chandran [Royaume-Uni] ; George Joy [Royaume-Uni] ; Cecilia Di Genova [Royaume-Uni] ; Nigel Temperton [Royaume-Uni] ; Jonathan Lambourne [Royaume-Uni] ; Teresa Cutino-Moguel [Royaume-Uni] ; Mervyn Andiapen [Royaume-Uni] ; Marianna Fontana [Royaume-Uni] ; Angelique Smit [Royaume-Uni] ; Amanda Semper [Royaume-Uni] ; Ben O'Brien [Royaume-Uni, Allemagne] ; Benjamin Chain [Royaume-Uni] ; Tim Brooks [Royaume-Uni] ; Charlotte Manisty [Royaume-Uni] ; Thomas Treibel [Royaume-Uni] ; James C. Moon [Royaume-Uni] ; Mahdad Noursadeghi [Royaume-Uni] ; Daniel M. Altmann [Royaume-Uni] ; Mala K. Maini [Royaume-Uni] ; Áine Mcknight [Royaume-Uni] ; Rosemary J. Boyton [Royaume-Uni]Source :
- Science immunology [ 2470-9468 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Antibodies, Neutralizing (blood), Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Antibodies, Viral (immunology), Asymptomatic Infections (MeSH), COVID-19 (immunology), Case-Control Studies (MeSH), Cross-Sectional Studies (MeSH), Humans (MeSH), SARS-CoV-2 (immunology), T-Lymphocytes (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral.
- immunology : COVID-19, SARS-CoV-2, T-Lymphocytes.
- Asymptomatic Infections, Case-Control Studies, Cross-Sectional Studies, Humans.
Abstract
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.
DOI: 10.1126/sciimmunol.abf3698
PubMed: 33361161
Affiliations:
- Allemagne, Royaume-Uni
- Angleterre, Berlin, Grand Londres
- Berlin, Londres
- University College de Londres, Université de Londres
Links toward previous steps (curation, corpus...)
Le document en format XML
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wicri:level="4"><nlm:affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Rosenheim, Joshua" sort="Rosenheim, Joshua" uniqKey="Rosenheim J" first="Joshua" last="Rosenheim">Joshua Rosenheim</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Chandran, Aneesh" sort="Chandran, Aneesh" uniqKey="Chandran A" first="Aneesh" last="Chandran">Aneesh Chandran</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Joy, George" sort="Joy, George" uniqKey="Joy G" first="George" last="Joy">George Joy</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Di Genova, Cecilia" sort="Di Genova, Cecilia" uniqKey="Di Genova C" first="Cecilia" last="Di Genova">Cecilia Di Genova</name><affiliation wicri:level="1"><nlm:affiliation>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent</wicri:regionArea><wicri:noRegion>Kent</wicri:noRegion></affiliation></author><author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name><affiliation wicri:level="1"><nlm:affiliation>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent</wicri:regionArea><wicri:noRegion>Kent</wicri:noRegion></affiliation></author><author><name sortKey="Lambourne, Jonathan" sort="Lambourne, Jonathan" uniqKey="Lambourne J" first="Jonathan" last="Lambourne">Jonathan Lambourne</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infection, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cutino Moguel, Teresa" sort="Cutino Moguel, Teresa" uniqKey="Cutino Moguel T" first="Teresa" last="Cutino-Moguel">Teresa Cutino-Moguel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Virology, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Andiapen, Mervyn" sort="Andiapen, Mervyn" uniqKey="Andiapen M" first="Mervyn" last="Andiapen">Mervyn Andiapen</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Fontana, Marianna" sort="Fontana, Marianna" uniqKey="Fontana M" first="Marianna" last="Fontana">Marianna Fontana</name><affiliation wicri:level="3"><nlm:affiliation>Royal Free London NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Free London NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Smit, Angelique" sort="Smit, Angelique" uniqKey="Smit A" first="Angelique" last="Smit">Angelique Smit</name><affiliation wicri:level="3"><nlm:affiliation>Royal Free London NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Free London NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Semper, Amanda" sort="Semper, Amanda" uniqKey="Semper A" first="Amanda" last="Semper">Amanda Semper</name><affiliation wicri:level="1"><nlm:affiliation>National Infection Service, Public Health England, Porton Down, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Infection Service, Public Health England, Porton Down</wicri:regionArea><wicri:noRegion>Porton Down</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, Ben" sort="O Brien, Ben" uniqKey="O Brien B" first="Ben" last="O'Brien">Ben O'Brien</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>German Heart Centre and Charité University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Heart Centre and Charité University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Chain, Benjamin" sort="Chain, Benjamin" uniqKey="Chain B" first="Benjamin" last="Chain">Benjamin Chain</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Brooks, Tim" sort="Brooks, Tim" uniqKey="Brooks T" first="Tim" last="Brooks">Tim Brooks</name><affiliation wicri:level="1"><nlm:affiliation>National Infection Service, Public Health England, Porton Down, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Infection Service, Public Health England, Porton Down</wicri:regionArea><wicri:noRegion>Porton Down</wicri:noRegion></affiliation></author><author><name sortKey="Manisty, Charlotte" sort="Manisty, Charlotte" uniqKey="Manisty C" first="Charlotte" last="Manisty">Charlotte Manisty</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Treibel, Thomas" sort="Treibel, Thomas" uniqKey="Treibel T" first="Thomas" last="Treibel">Thomas Treibel</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Moon, James C" sort="Moon, James C" uniqKey="Moon J" first="James C" last="Moon">James C. Moon</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Noursadeghi, Mahdad" sort="Noursadeghi, Mahdad" uniqKey="Noursadeghi M" first="Mahdad" last="Noursadeghi">Mahdad Noursadeghi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Altmann, Daniel M" sort="Altmann, Daniel M" uniqKey="Altmann D" first="Daniel M" last="Altmann">Daniel M. Altmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Inflammation, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Immunology and Inflammation, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Maini, Mala K" sort="Maini, Mala K" uniqKey="Maini M" first="Mala K" last="Maini">Mala K. Maini</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mcknight, Aine" sort="Mcknight, Aine" uniqKey="Mcknight A" first="Áine" last="Mcknight">Áine Mcknight</name><affiliation wicri:level="4"><nlm:affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Boyton, Rosemary J" sort="Boyton, Rosemary J" uniqKey="Boyton R" first="Rosemary J" last="Boyton">Rosemary J. Boyton</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease, Imperial College London, London, UK. r.boyton@imperial.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33361161</idno><idno type="pmid">33361161</idno><idno type="doi">10.1126/sciimmunol.abf3698</idno><idno type="wicri:Area/Main/Corpus">000594</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000594</idno><idno type="wicri:Area/Main/Curation">000594</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000594</idno><idno type="wicri:Area/Main/Exploration">000594</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.</title><author><name sortKey="Reynolds, Catherine J" sort="Reynolds, Catherine J" uniqKey="Reynolds C" first="Catherine J" last="Reynolds">Catherine J. Reynolds</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Swadling, Leo" sort="Swadling, Leo" uniqKey="Swadling L" first="Leo" last="Swadling">Leo Swadling</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Gibbons, Joseph M" sort="Gibbons, Joseph M" uniqKey="Gibbons J" first="Joseph M" last="Gibbons">Joseph M. Gibbons</name><affiliation wicri:level="4"><nlm:affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Pade, Corinna" sort="Pade, Corinna" uniqKey="Pade C" first="Corinna" last="Pade">Corinna Pade</name><affiliation wicri:level="4"><nlm:affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Jensen, Melanie P" sort="Jensen, Melanie P" uniqKey="Jensen M" first="Melanie P" last="Jensen">Melanie P. Jensen</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Diniz, Mariana O" sort="Diniz, Mariana O" uniqKey="Diniz M" first="Mariana O" last="Diniz">Mariana O. Diniz</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Schmidt, Nathalie M" sort="Schmidt, Nathalie M" uniqKey="Schmidt N" first="Nathalie M" last="Schmidt">Nathalie M. Schmidt</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Butler, David K" sort="Butler, David K" uniqKey="Butler D" first="David K" last="Butler">David K. Butler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Amin, Oliver E" sort="Amin, Oliver E" uniqKey="Amin O" first="Oliver E" last="Amin">Oliver E. Amin</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Bailey, Sasha N L" sort="Bailey, Sasha N L" uniqKey="Bailey S" first="Sasha N L" last="Bailey">Sasha N L. Bailey</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Murray, Sam M" sort="Murray, Sam M" uniqKey="Murray S" first="Sam M" last="Murray">Sam M. Murray</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pieper, Franziska P" sort="Pieper, Franziska P" uniqKey="Pieper F" first="Franziska P" last="Pieper">Franziska P. Pieper</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Taylor, Stephen" sort="Taylor, Stephen" uniqKey="Taylor S" first="Stephen" last="Taylor">Stephen Taylor</name><affiliation wicri:level="1"><nlm:affiliation>National Infection Service, Public Health England, Porton Down, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Infection Service, Public Health England, Porton Down</wicri:regionArea><wicri:noRegion>Porton Down</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Jessica" sort="Jones, Jessica" uniqKey="Jones J" first="Jessica" last="Jones">Jessica Jones</name><affiliation wicri:level="1"><nlm:affiliation>National Infection Service, Public Health England, Porton Down, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Infection Service, Public Health England, Porton Down</wicri:regionArea><wicri:noRegion>Porton Down</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Meleri" sort="Jones, Meleri" uniqKey="Jones M" first="Meleri" last="Jones">Meleri Jones</name><affiliation wicri:level="4"><nlm:affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Lee, Wing Yiu Jason" sort="Lee, Wing Yiu Jason" uniqKey="Lee W" first="Wing-Yiu Jason" last="Lee">Wing-Yiu Jason Lee</name><affiliation wicri:level="4"><nlm:affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Rosenheim, Joshua" sort="Rosenheim, Joshua" uniqKey="Rosenheim J" first="Joshua" last="Rosenheim">Joshua Rosenheim</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Chandran, Aneesh" sort="Chandran, Aneesh" uniqKey="Chandran A" first="Aneesh" last="Chandran">Aneesh Chandran</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Joy, George" sort="Joy, George" uniqKey="Joy G" first="George" last="Joy">George Joy</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Di Genova, Cecilia" sort="Di Genova, Cecilia" uniqKey="Di Genova C" first="Cecilia" last="Di Genova">Cecilia Di Genova</name><affiliation wicri:level="1"><nlm:affiliation>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent</wicri:regionArea><wicri:noRegion>Kent</wicri:noRegion></affiliation></author><author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name><affiliation wicri:level="1"><nlm:affiliation>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent</wicri:regionArea><wicri:noRegion>Kent</wicri:noRegion></affiliation></author><author><name sortKey="Lambourne, Jonathan" sort="Lambourne, Jonathan" uniqKey="Lambourne J" first="Jonathan" last="Lambourne">Jonathan Lambourne</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infection, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cutino Moguel, Teresa" sort="Cutino Moguel, Teresa" uniqKey="Cutino Moguel T" first="Teresa" last="Cutino-Moguel">Teresa Cutino-Moguel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Virology, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Andiapen, Mervyn" sort="Andiapen, Mervyn" uniqKey="Andiapen M" first="Mervyn" last="Andiapen">Mervyn Andiapen</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Fontana, Marianna" sort="Fontana, Marianna" uniqKey="Fontana M" first="Marianna" last="Fontana">Marianna Fontana</name><affiliation wicri:level="3"><nlm:affiliation>Royal Free London NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Free London NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Smit, Angelique" sort="Smit, Angelique" uniqKey="Smit A" first="Angelique" last="Smit">Angelique Smit</name><affiliation wicri:level="3"><nlm:affiliation>Royal Free London NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Free London NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Semper, Amanda" sort="Semper, Amanda" uniqKey="Semper A" first="Amanda" last="Semper">Amanda Semper</name><affiliation wicri:level="1"><nlm:affiliation>National Infection Service, Public Health England, Porton Down, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Infection Service, Public Health England, Porton Down</wicri:regionArea><wicri:noRegion>Porton Down</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, Ben" sort="O Brien, Ben" uniqKey="O Brien B" first="Ben" last="O'Brien">Ben O'Brien</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>German Heart Centre and Charité University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Heart Centre and Charité University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Chain, Benjamin" sort="Chain, Benjamin" uniqKey="Chain B" first="Benjamin" last="Chain">Benjamin Chain</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Brooks, Tim" sort="Brooks, Tim" uniqKey="Brooks T" first="Tim" last="Brooks">Tim Brooks</name><affiliation wicri:level="1"><nlm:affiliation>National Infection Service, Public Health England, Porton Down, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Infection Service, Public Health England, Porton Down</wicri:regionArea><wicri:noRegion>Porton Down</wicri:noRegion></affiliation></author><author><name sortKey="Manisty, Charlotte" sort="Manisty, Charlotte" uniqKey="Manisty C" first="Charlotte" last="Manisty">Charlotte Manisty</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Treibel, Thomas" sort="Treibel, Thomas" uniqKey="Treibel T" first="Thomas" last="Treibel">Thomas Treibel</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Moon, James C" sort="Moon, James C" uniqKey="Moon J" first="James C" last="Moon">James C. Moon</name><affiliation wicri:level="3"><nlm:affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Science, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Noursadeghi, Mahdad" sort="Noursadeghi, Mahdad" uniqKey="Noursadeghi M" first="Mahdad" last="Noursadeghi">Mahdad Noursadeghi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Altmann, Daniel M" sort="Altmann, Daniel M" uniqKey="Altmann D" first="Daniel M" last="Altmann">Daniel M. Altmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Inflammation, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Immunology and Inflammation, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Maini, Mala K" sort="Maini, Mala K" uniqKey="Maini M" first="Mala K" last="Maini">Mala K. Maini</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Infection and Immunity, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mcknight, Aine" sort="Mcknight, Aine" uniqKey="Mcknight A" first="Áine" last="Mcknight">Áine Mcknight</name><affiliation wicri:level="4"><nlm:affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Boyton, Rosemary J" sort="Boyton, Rosemary J" uniqKey="Boyton R" first="Rosemary J" last="Boyton">Rosemary J. Boyton</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease, Imperial College London, London, UK. r.boyton@imperial.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Science immunology</title><idno type="eISSN">2470-9468</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (immunology)</term><term>Asymptomatic Infections (MeSH)</term><term>COVID-19 (immunology)</term><term>Case-Control Studies (MeSH)</term><term>Cross-Sectional Studies (MeSH)</term><term>Humans (MeSH)</term><term>SARS-CoV-2 (immunology)</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (immunologie)</term><term>Anticorps neutralisants (sang)</term><term>Humains (MeSH)</term><term>Infections asymptomatiques (MeSH)</term><term>Lymphocytes T (immunologie)</term><term>Études cas-témoins (MeSH)</term><term>Études transversales (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>COVID-19</term><term>SARS-CoV-2</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Asymptomatic Infections</term><term>Case-Control Studies</term><term>Cross-Sectional Studies</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Infections asymptomatiques</term><term>Études cas-témoins</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33361161</PMID><DateCompleted><Year>2021</Year><Month>01</Month><Day>07</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2470-9468</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>54</Issue><PubDate><Year>2020</Year><Month>12</Month><Day>23</Day></PubDate></JournalIssue><Title>Science immunology</Title><ISOAbbreviation>Sci Immunol</ISOAbbreviation></Journal><ArticleTitle>Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">eabf3698</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1126/sciimmunol.abf3698</ELocationID><Abstract><AbstractText>Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.</AbstractText><CopyrightInformation>Copyright © 2020, American Association for the Advancement of Science.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Reynolds</LastName><ForeName>Catherine J</ForeName><Initials>CJ</Initials><Identifier Source="ORCID">0000-0002-1371-653X</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Swadling</LastName><ForeName>Leo</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0002-0537-6715</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Gibbons</LastName><ForeName>Joseph M</ForeName><Initials>JM</Initials><Identifier Source="ORCID">0000-0002-7238-2381</Identifier><AffiliationInfo><Affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Pade</LastName><ForeName>Corinna</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0003-0626-2346</Identifier><AffiliationInfo><Affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jensen</LastName><ForeName>Melanie P</ForeName><Initials>MP</Initials><Identifier Source="ORCID">0000-0002-2027-5023</Identifier><AffiliationInfo><Affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diniz</LastName><ForeName>Mariana O</ForeName><Initials>MO</Initials><Identifier Source="ORCID">0000-0002-1961-0189</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Nathalie M</ForeName><Initials>NM</Initials><Identifier Source="ORCID">0000-0002-9841-8418</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butler</LastName><ForeName>David K</ForeName><Initials>DK</Initials><Identifier Source="ORCID">0000-0003-1882-8159</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin</LastName><ForeName>Oliver E</ForeName><Initials>OE</Initials><Identifier Source="ORCID">0000-0003-3663-1253</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>Sasha N L</ForeName><Initials>SNL</Initials><Identifier Source="ORCID">0000-0002-6291-3417</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murray</LastName><ForeName>Sam M</ForeName><Initials>SM</Initials><Identifier Source="ORCID">0000-0002-5990-5854</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pieper</LastName><ForeName>Franziska P</ForeName><Initials>FP</Initials><Identifier Source="ORCID">0000-0002-4857-0518</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-9936-8539</Identifier><AffiliationInfo><Affiliation>National Infection Service, Public Health England, Porton Down, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-8298-0609</Identifier><AffiliationInfo><Affiliation>National Infection Service, Public Health England, Porton Down, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Meleri</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-9158-2971</Identifier><AffiliationInfo><Affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Wing-Yiu Jason</ForeName><Initials>WJ</Initials><Identifier Source="ORCID">0000-0002-8524-3874</Identifier><AffiliationInfo><Affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosenheim</LastName><ForeName>Joshua</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0003-0171-2053</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chandran</LastName><ForeName>Aneesh</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0003-1027-2862</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joy</LastName><ForeName>George</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0003-1467-5490</Identifier><AffiliationInfo><Affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Genova</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0002-2121-0715</Identifier><AffiliationInfo><Affiliation>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Temperton</LastName><ForeName>Nigel</ForeName><Initials>N</Initials><Identifier Source="ORCID">0000-0002-7978-3815</Identifier><AffiliationInfo><Affiliation>Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lambourne</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-3458-6922</Identifier><AffiliationInfo><Affiliation>Department of Infection, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cutino-Moguel</LastName><ForeName>Teresa</ForeName><Initials>T</Initials><Identifier Source="ORCID">0000-0002-1726-4278</Identifier><AffiliationInfo><Affiliation>Department of Virology, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andiapen</LastName><ForeName>Mervyn</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-1796-0214</Identifier><AffiliationInfo><Affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fontana</LastName><ForeName>Marianna</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-9233-9831</Identifier><AffiliationInfo><Affiliation>Royal Free London NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smit</LastName><ForeName>Angelique</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-2144-1249</Identifier><AffiliationInfo><Affiliation>Royal Free London NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Semper</LastName><ForeName>Amanda</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0003-3656-1363</Identifier><AffiliationInfo><Affiliation>National Infection Service, Public Health England, Porton Down, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Brien</LastName><ForeName>Ben</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0001-7024-2337</Identifier><AffiliationInfo><Affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Heart Centre and Charité University, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chain</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0002-7417-3970</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brooks</LastName><ForeName>Tim</ForeName><Initials>T</Initials><Identifier Source="ORCID">0000-0002-3783-1284</Identifier><AffiliationInfo><Affiliation>National Infection Service, Public Health England, Porton Down, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manisty</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0003-0245-7090</Identifier><AffiliationInfo><Affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Treibel</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><Identifier Source="ORCID">0000-0003-1560-7414</Identifier><AffiliationInfo><Affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moon</LastName><ForeName>James C</ForeName><Initials>JC</Initials><Identifier Source="ORCID">0000-0001-8071-1491</Identifier><AffiliationInfo><Affiliation>Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COVIDsortium investigators</CollectiveName></Author><Author ValidYN="Y"><LastName>Noursadeghi</LastName><ForeName>Mahdad</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-4774-0853</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COVIDsortium immune correlates network</CollectiveName></Author><Author ValidYN="Y"><LastName>Altmann</LastName><ForeName>Daniel M</ForeName><Initials>DM</Initials><Identifier Source="ORCID">0000-0002-2436-6192</Identifier><AffiliationInfo><Affiliation>Department of Immunology and Inflammation, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maini</LastName><ForeName>Mala K</ForeName><Initials>MK</Initials><Identifier Source="ORCID">0000-0001-6384-1462</Identifier><AffiliationInfo><Affiliation>Division of Infection and Immunity, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McKnight</LastName><ForeName>Áine</ForeName><Initials>Á</Initials><Identifier Source="ORCID">0000-0002-8113-817X</Identifier><AffiliationInfo><Affiliation>Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyton</LastName><ForeName>Rosemary J</ForeName><Initials>RJ</Initials><Identifier Source="ORCID">0000-0002-5608-0797</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease, Imperial College London, London, UK. r.boyton@imperial.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>214191/Z/18/Z</GrantID><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>207511/Z/17/Z</GrantID><Acronym>WT_</Acronym><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Sci Immunol</MedlineTA><NlmUniqueID>101688624</NlmUniqueID><ISSNLinking>2470-9468</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058345" MajorTopicYN="Y">Asymptomatic Infections</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>10</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>12</Month><Day>28</Day><Hour>11</Hour><Minute>40</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>12</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>1</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33361161</ArticleId><ArticleId IdType="pii">5/54/eabf3698</ArticleId><ArticleId IdType="doi">10.1126/sciimmunol.abf3698</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Berlin</li><li>Grand Londres</li></region><settlement><li>Berlin</li><li>Londres</li></settlement><orgName><li>University College de Londres</li><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Reynolds, Catherine J" sort="Reynolds, Catherine J" uniqKey="Reynolds C" first="Catherine J" last="Reynolds">Catherine J. Reynolds</name></region><name sortKey="Altmann, Daniel M" sort="Altmann, Daniel M" uniqKey="Altmann D" first="Daniel M" last="Altmann">Daniel M. Altmann</name><name sortKey="Amin, Oliver E" sort="Amin, Oliver E" uniqKey="Amin O" first="Oliver E" last="Amin">Oliver E. Amin</name><name sortKey="Andiapen, Mervyn" sort="Andiapen, Mervyn" uniqKey="Andiapen M" first="Mervyn" last="Andiapen">Mervyn Andiapen</name><name sortKey="Bailey, Sasha N L" sort="Bailey, Sasha N L" uniqKey="Bailey S" first="Sasha N L" last="Bailey">Sasha N L. Bailey</name><name sortKey="Boyton, Rosemary J" sort="Boyton, Rosemary J" uniqKey="Boyton R" first="Rosemary J" last="Boyton">Rosemary J. Boyton</name><name sortKey="Boyton, Rosemary J" sort="Boyton, Rosemary J" uniqKey="Boyton R" first="Rosemary J" last="Boyton">Rosemary J. Boyton</name><name sortKey="Brooks, Tim" sort="Brooks, Tim" uniqKey="Brooks T" first="Tim" last="Brooks">Tim Brooks</name><name sortKey="Butler, David K" sort="Butler, David K" uniqKey="Butler D" first="David K" last="Butler">David K. Butler</name><name sortKey="Chain, Benjamin" sort="Chain, Benjamin" uniqKey="Chain B" first="Benjamin" last="Chain">Benjamin Chain</name><name sortKey="Chandran, Aneesh" sort="Chandran, Aneesh" uniqKey="Chandran A" first="Aneesh" last="Chandran">Aneesh Chandran</name><name sortKey="Cutino Moguel, Teresa" sort="Cutino Moguel, Teresa" uniqKey="Cutino Moguel T" first="Teresa" last="Cutino-Moguel">Teresa Cutino-Moguel</name><name sortKey="Di Genova, Cecilia" sort="Di Genova, Cecilia" uniqKey="Di Genova C" first="Cecilia" last="Di Genova">Cecilia Di Genova</name><name sortKey="Diniz, Mariana O" sort="Diniz, Mariana O" uniqKey="Diniz M" first="Mariana O" last="Diniz">Mariana O. 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Maini</name><name sortKey="Manisty, Charlotte" sort="Manisty, Charlotte" uniqKey="Manisty C" first="Charlotte" last="Manisty">Charlotte Manisty</name><name sortKey="Manisty, Charlotte" sort="Manisty, Charlotte" uniqKey="Manisty C" first="Charlotte" last="Manisty">Charlotte Manisty</name><name sortKey="Mcknight, Aine" sort="Mcknight, Aine" uniqKey="Mcknight A" first="Áine" last="Mcknight">Áine Mcknight</name><name sortKey="Moon, James C" sort="Moon, James C" uniqKey="Moon J" first="James C" last="Moon">James C. Moon</name><name sortKey="Moon, James C" sort="Moon, James C" uniqKey="Moon J" first="James C" last="Moon">James C. Moon</name><name sortKey="Murray, Sam M" sort="Murray, Sam M" uniqKey="Murray S" first="Sam M" last="Murray">Sam M. Murray</name><name sortKey="Noursadeghi, Mahdad" sort="Noursadeghi, Mahdad" uniqKey="Noursadeghi M" first="Mahdad" last="Noursadeghi">Mahdad Noursadeghi</name><name sortKey="O Brien, Ben" sort="O Brien, Ben" uniqKey="O Brien B" first="Ben" last="O'Brien">Ben O'Brien</name><name sortKey="O Brien, Ben" sort="O Brien, Ben" uniqKey="O Brien B" first="Ben" last="O'Brien">Ben O'Brien</name><name sortKey="Pade, Corinna" sort="Pade, Corinna" uniqKey="Pade C" first="Corinna" last="Pade">Corinna Pade</name><name sortKey="Pieper, Franziska P" sort="Pieper, Franziska P" uniqKey="Pieper F" first="Franziska P" last="Pieper">Franziska P. Pieper</name><name sortKey="Rosenheim, Joshua" sort="Rosenheim, Joshua" uniqKey="Rosenheim J" first="Joshua" last="Rosenheim">Joshua Rosenheim</name><name sortKey="Schmidt, Nathalie M" sort="Schmidt, Nathalie M" uniqKey="Schmidt N" first="Nathalie M" last="Schmidt">Nathalie M. Schmidt</name><name sortKey="Semper, Amanda" sort="Semper, Amanda" uniqKey="Semper A" first="Amanda" last="Semper">Amanda Semper</name><name sortKey="Smit, Angelique" sort="Smit, Angelique" uniqKey="Smit A" first="Angelique" last="Smit">Angelique Smit</name><name sortKey="Swadling, Leo" sort="Swadling, Leo" uniqKey="Swadling L" first="Leo" last="Swadling">Leo Swadling</name><name sortKey="Taylor, Stephen" sort="Taylor, Stephen" uniqKey="Taylor S" first="Stephen" last="Taylor">Stephen Taylor</name><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name><name sortKey="Treibel, Thomas" sort="Treibel, Thomas" uniqKey="Treibel T" first="Thomas" last="Treibel">Thomas Treibel</name><name sortKey="Treibel, Thomas" sort="Treibel, Thomas" uniqKey="Treibel T" first="Thomas" last="Treibel">Thomas Treibel</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="O Brien, Ben" sort="O Brien, Ben" uniqKey="O Brien B" first="Ben" last="O'Brien">Ben O'Brien</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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